A major milestone in Florida’s tourism and hospitality development is on the horizon as the Hilton Jacksonville at Mayo Clinic prepares to open its doors in October 2025. This 252-room luxury property is strategically located adjacent to the renowned Mayo Clinic in Northeast Florida, positioning itself as both a medical tourism hub and upscale leisure destination.
A Strategic Location Blending Care and Culture
The new Hilton hotel offers a uniquely situated retreat for patients, families, and travelers seeking proximity to the Mayo Clinic Jacksonville — ranked among the top hospitals in the United States by U.S. News & World Report. With an increasing number of domestic and international patients choosing the Mayo Clinic for advanced medical care, the hotel is expected to provide convenient, comforting accommodations for wellness-driven travel.
Beyond its medical tourism appeal, the property lies just minutes from top Jacksonville attractions, including Jacksonville Beach, St. Johns Town Center, the Museum of Science & History, and the Cummer Museum of Art & Gardens. This prime location ensures guests can explore the best of Northeast Florida, whether relaxing seaside or discovering cultural gems.
Elevated Accommodations and Premium Guest Experience
Hilton Jacksonville at Mayo Clinic features 252 well-appointed guest rooms and 21 upscale suites, each thoughtfully designed to balance modern luxury with tranquil aesthetics. Rooms are equipped with premium bedding, flat-panel televisions, high-speed internet, and spa-inspired bathrooms. Select suites include private patios or balconies with serene views of surrounding nature.
The architectural design prioritizes wellness and calm, using locally sourced natural materials and eco-conscious features to reflect the beauty of Northeast Florida while promoting sustainability.
Wellness-Centered Amenities and Locally Inspired Dining
Guests can unwind at the hotel’s outdoor heated pool or stay active in the on-site fitness center, complete with the latest wellness equipment. The in-house restaurant, Coastal Kitchen, will specialize in fresh, seasonal cuisine sourced from local farms and Florida’s coastal waters — including artisanal pizzas and seafood-forward entrees.
For guests on the go, the lobby café offers grab-and-go items, smoothies, and locally roasted coffee, perfect for busy professionals or family members in need of quick yet healthy options.
State-of-the-Art Event and Meeting Facilities
Hilton Jacksonville at Mayo Clinic will offer more than 21,000 square feet of flexible meeting and event space, including a grand ballroom, junior ballrooms, executive boardrooms, and a scenic outdoor event lawn overlooking water features. Designed for versatility, the spaces cater to business conferences, corporate retreats, weddings, and social gatherings.
The inclusion of cutting-edge audiovisual technology, dedicated event planners, and customizable catering ensures an exceptional experience for attendees.
Supporting Jacksonville’s Tourism Growth and Sustainability
The hotel launch comes at a time of rapid tourism growth in Jacksonville. According to Visit Jacksonville, the city welcomed over 24 million visitors in 2024, with continued growth expected in 2025 driven by business travel, health tourism, and beach-focused vacations.
Hilton Jacksonville at Mayo Clinic also contributes to Jacksonville’s eco-tourism goals. Managed by Remington Hotels, the property participates in “The Green Room” sustainability initiative, which includes aluminum recycling in partnership with Clean the World, LED lighting upgrades, water conservation systems, and smart energy management technology.
These programs align with Hilton’s “Travel with Purpose” strategy, which commits to cutting environmental impact by half and doubling social investment by 2030.
A Gateway to Northeast Florida’s Natural and Cultural Riches
From the Atlantic coastline to historic neighborhoods and green urban spaces, Jacksonville continues to attract a broad spectrum of visitors. Just a short drive from the Hilton, Jacksonville Beach offers opportunities for surfing, paddleboarding, and waterfront dining, while nearby parks like Kathryn Abbey Hanna Park provide trails and kayak access to pristine coastal ecosystems.
Shopping enthusiasts can explore luxury brands and local boutiques at St. Johns Town Center, one of the Southeast’s premier lifestyle centers. Families will enjoy educational excursions to the Jacksonville Zoo and Gardens and MOSH (Museum of Science & History), both of which are less than 30 minutes from the hotel.
A Flagship Hilton Property in Jacksonville
Hilton Jacksonville at Mayo Clinic is the first Hilton Hotels & Resorts property in Jacksonville, marking a significant milestone in the brand’s Northeast Florida presence. As part of Hilton’s global portfolio of over 7,600 properties, this flagship hotel brings internationally recognized service standards to a city poised for increased tourism recognition.
Its opening reinforces Jacksonville’s positioning as a key destination for domestic and international travel, further integrating the city into Florida’s broader tourism strategy, which attracted more than 137 million visitors statewide in 2024, according to Visit Florida.
Conclusion
Whether traveling for health, business, or leisure, Hilton Jacksonville at Mayo Clinic offers a refined and wellness-centric stay tailored to the evolving needs of modern travelers. The hotel’s thoughtful design, sustainable operations, and prime location near Jacksonville’s top attractions position it as a game-changing addition to the region’s tourism infrastructure.
As Jacksonville continues to rise as a vibrant travel destination, Hilton’s debut in the city signals a bold step forward in hospitality excellence and reinforces Florida’s commitment to innovation, wellness, and accessibility in tourism.
For more travel news like this, keep reading Global Travel Wire